In fairness to 23andME, it leaves it up to the customer to unlock the more serious results – or not. When I unlock mine, I discover that, while I’m not genetically predisposed to such things as the BRAC1 or BRAC2 variant, Parkinson’s or MS, I have one of the variants for late-onset (mid-80s) Alzheimer’s. However, I don’t have any other markers for Alzheimer’s or family history or conditions associated with it or anything else listed in the rather lengthy disclaimer, which also stresses that it’s not a diagnostic result and to seek further advice from your GP if you are concerned.
If you want to keep things really simple then we recommend 23andMe as it offers the best all-round DNA testing kit. It offers a mix of everything including family matching, ancestry percentages and optional heath insights. If you’re more interested in your genealogy then the AncestryDNA kit provides more detail along a gene pool and family tree. The National Geographic Geno 2.0 DNA kit is the best kit for connecting your genes to history going back up to 100,000 years.
Each of the kits work similarly: You answer a few questions about yourself, order the kit, collect your sample, register the kit (this is very important), send it back, and wait for the results. That said, they differ in the collection process and, to a smaller extent, the cost of shipping. When we tested 23andMe back in mid-2015, the company was unable to accept DNA samples collected in or sent from New York State, because of local laws (we had to cross the border to New Jersey). The company was also prohibited from shipping DNA kits to Maryland.
There are many places you can upload your raw DNA, and several of them are free. Popular third-party DNA analysis tools include GEDmatch and Promethese. GEDmatch is a free, open database and genealogy site that gives additional DNA relative matching and trait results. This tool has information from users of multiple different testing companies. Promethease compares your raw DNA information against scientific reports that link certain markers to health conditions, though you should take these results with a grain of salt as genetic links do not equal a diagnosis.
Rather than simply looking at your DNA in isolation, the Findmypast DNA test analyses unique combinations of linked DNA. This proprietary method delivers a level of detail impossible with other ancestry DNA tests. It also uses the latest technology, which is constantly updated in response to the latest industry innovations and peer-reviewed research. As the technology evolves so too does the detail of your test results, which will receive free ongoing upgrades.
This is a large amount of data not being used by services testing DNA. There are millions of SNP’s contained in your DNA. This type of testing only looks at specific variations. This requires between 100 and 300 AIM’s. This is a small fraction of the SNP’s differentiating DNA. This means if your test stated you are fifty percent European, it means only half of your SNP’s appear to be European. Another issue is certain markers used for ancestry information for any given test are only derived from either your Y chromosomes or your paternal line or your mitochondrial DNA or maternal line. When these markers are used, your test will be less accurate. Another flaw is the DNA testing services are obtaining DNA from the current populations in specific regions. This makes unsubstantiated conclusions that the people living in these areas hundreds of thousands of years in the past have had the same DNA for all these years.
So I get my DNA result and it has even less information than what my address can tell about me. They say they don't have have much information on the area am from. But that's not something they tell you when you buy. Furthermore half the information is incorrect. Called customer services and the answer is - Sorry you feel that way, nothing we can do. DO NOT SPEND YOUR MONEY HERE. MIGHT AS WELL BURN IT!!!
If you opt in to DNA Relatives, you will be able to send and receive invitations to connect with other customers who share DNA with you. You can choose whether to respond to these invitations or not, and your DNA relatives have the same choice. We cannot guarantee that they will respond to your sharing invitations or messages. Regardless of whether you both agree to share, you will be able to see their birthplace, locations of their ancestors and surnames, if they have chosen to add this information to their profile. If you both accept sharing invitations, you will be able to see ancestry reports and overlapping chromosome segments.
Most direct-to-consumer DNA test companies warn that the tests may reveal things you wish you didn’t know about your family. For example, you could find out that one of the people who raised you isn’t your biological parent or that there’s an entire branch of your family you didn’t know about. There isn’t a way to prepare for a shock like that, but you can opt out of a company’s family-matching services if you’d rather not know.
The first kit I try is Thriva’s baseline test (£49), which, like all its products, checks your blood. The box arrives promptly enough (containing spring-loaded needles, a little collection tube, antiseptic wipes, plasters, etc), but there’s a problem. The idea is to prick your finger and massage blood into the tube, but I just end up making my fingers sore and what I get out barely smears the top of the phial. Maybe it’s just me, but it turns into a right faff. In the end, I take advantage of Thriva’s service to send someone out to take a sample of blood from my arm.