Men have an X and a Y (chromosome) that are paired together. Women don’t have the Y, they just have two X’s. A child’s genes come from a mix up and recombining of the two parents. So a girl child will still end up with two X’s but some bits of them will come from the father’s X and some from the mother’s. A boy child on the other hand may have some bits of X from both mother and father, but his Y will have just come purely from his father – virtually unchanged. That makes Y-DNA such an exciting possibility for genealogy where you want to follow the paternal (surname) line. You could expect that Y-DNA will therefore pass virtually unchanged from father to son through the generations, meaning that the Y-DNA of a man’s g-g-g-g-grandfather will look very much like that of his own Y-DNA – with some little changes.
We have zeroed in on autosomal tests only. These tests are used to give you the ancestry percentages and cousin matching most people are seeking. If you are interested in YDNA (paternal line only, for men) or mtDNA (maternal line only) you can find these tests at Family Tree DNA. 23andMe also offers limited motherline and fatherline results as part of this main ancestry test.
Rather than simply looking at your DNA in isolation, the Findmypast DNA test analyses unique combinations of linked DNA. This proprietary method delivers a level of detail impossible with other ancestry DNA tests. It also uses the latest technology, which is constantly updated in response to the latest industry innovations and peer-reviewed research. As the technology evolves so too does the detail of your test results, which will receive free ongoing upgrades.
The technique of DNA profiling was developed by Alec Jefferys in the mid-1980s and is based on the analysis of markers in DNA known as microsatellites or Short Tandem Repeats (STRs). These markers are found at specific points (also called loci) in everyone’s DNA and they’re motifs of two-six bases (the units that make up our genes) that are repeated numerous times. The exact number of times these markers are repeated differs between individuals, but members of a family will share the same or a similar number of repeated markers, depending on how closely related they are.
Our testers received notifications that our samples were received 15 days after we mailed them. The email also said that it would take approximately six to eight weeks from that point for results. It actually only took 17 days after the email to get our results notifications. From mailing our samples back to collection, all in all, was 32 days. This was slower than several other DNA services, including the speedy MyHeritage DNA, which had a 16-day turnaround.
In addition to showing geographic ancestry percentages, some direct-to-consumer DNA tests also include insights about physical traits like hair and eye color. With 23andMe, this trait information is mostly available in the upgraded Ancestry + Health kit, but some interesting tidbits can be found in the Your DNA Family report, which is available if you opt to participate in the DNA Relatives service.
All this comes into sharp focus with the comprehensive kits such as the one provided by 23andMe: the one I drool into a tube for (incidentally, 23andMe doesn’t test for Huntington’s disease). Most people, like myself, have a low understanding of genetic variants, what phrases such as “higher risk” or “probability” actually mean or how to interpret our results correctly. Is it right that ordinary members of the public must navigate potentially frightening and/or misleading results alone?
I took the AncestryDNA test in 2016 and was disappointed by my initial report, which put my results into a giant area encompassing at least 15 countries labeled “Asia East.” Since then, Ancestry has updated its algorithm and reference population to make its results more specific, but it still only supports 17 regions in Asia and West Asia compared to 296 regions in Europe.
Most of this trait data tells you things you already know, like your hair and eye color, but it is fun to see them compared to your genetic relatives and the world at large. We also found it fascinating to learn more about how these physical traits are genetically determined. For example, finger length ratio is determined by hormonal exposure in the womb, with higher testosterone exposure resulting in a better chance of having a longer ring finger. 23andMe’s Health report for finger length ratio looks at 15 gene markers to estimate your likelihood of having longer ring fingers or index fingers.
There are a ton of health and wellness DNA tests. We found several specifically oriented to dieting and weight loss, including embodyDNA, Vitagene, DNAFit and the several options available through the Helix marketplace. While there definitely are some links between DNA and factors that contribute to weight, we advise taking these diet plans with a grain of salt, as DNA science is still a relatively young field.
A DNA profile can also be adapted to produce artwork. Several companies will use the profiling technique discussed above, but they’ll combine florescent colours with your genetic markers to produce bands that look a bit like a barcode. These bands can be mounted on canvas, wood, metal or other materials to create a piece of art that can be displayed in your home. They can also be digitised and customised with different colours or background themes to make a range of ‘DNA portraits’. One company, Dot One, even makes scarves and rugs inspired by these patterns!
Who knows how much of it made solid scientific sense? However, I have to confess that I rather enjoyed it on the level of an indulgent genome-oriented “pampering session”, just as I had a hoot with the ancestry/Neanderthal/earlobe data on 23andMe. Where Thriva is concerned, I also noted that it did advanced thyroid tests. Although such tests are available from the NHS, I’m hypothyroid myself and I know that sometimes it can be difficult and time-consuming getting tests repeated and it could be useful to be privately tested in this way.
G6PD deficiency is a common genetic condition caused by defects in an enzyme called glucose-6-phosphate dehydrogenase, or G6PD. The G6PD enzyme helps protect red blood cells from damage. In people with G6PD deficiency, red blood cells are destroyed upon exposure to certain environmental triggers, which can lead to episodes of anemia. This test includes the most common variant linked to G6PD deficiency in people of African descent.
— Once you have chosen a test and received your autosomal results there is still a great deal more fun to be had. Independent tools and websites created by scientists and enthusiasts allow you to take the raw data provided from FTDNA, 23andMe and Ancestry DNA and explore them in astounding detail–giving you a wide variety of new admixtures, phasing options, chromosome browsers, SNP tools and connections with family across the world. Gedmatch is our favorite because they have so many wonderful and meticulously updated tools from a variety of sources. Easily upload your raw data and run your results for free (if you love the tools, don’t forget to donate and uncover even more options.)