Prices range from £100 to £200 for a basic DNA profile, but it’s worth mentioning that the cost largely depends on what you intend to do with it. One of the major factors that you need to consider, and which significantly impacts the cost, is whether you want your DNA profile to be legally admissible or not. Legal DNA profiles cost more than peace of mind versions, but if there’s a chance that your profile will be used in legal proceedings, it’s worth paying extra for.
I used 23&me, (who has around 80 geographical regions) and while I was disappointed with the nationality results, it was only because I thought they were a bit vague – but in all honesty, I didn’t really know what to expect, so there’s that. Now understanding a little more about the limitations of results from any company, have no problem with what I received.
Bill Newman, professor of translational genomic medicine in the Manchester centre for genomic medicine at the University of Manchester, and chair of the British Society of Genetic Medicine, says that such tests in this context simply don’t make sense and that, usually, telomere testing would only be used in in-depth studies of ageing and diseases associated with ageing. “There’s some really brilliant work going on, by some of the best biologists in the world,” says Newman, citing Elizabeth Blackburn, who won the 2009 Nobel prize for medicine for her work on telomeres. “But there’s no evidence whatsoever that measuring a person’s telomeres gives any indication about their health – or beauty, intelligence, or anything else that might be listed on these sites.”
Even though we are all unique, most of our DNA is actually identical to other people’s DNA. However, specific regions vary highly between people. These regions are called polymorphic. Differences in these variable regions between people are known as polymorphisms. Each of us inherits a unique combination of polymorphisms from our parents. DNA polymorphisms can be analysed to give a DNA profile.
Specific genetic variants in the BRCA1 and BRCA2 genes are associated with an increased risk of developing certain cancers, including breast cancer (in women and men) and ovarian cancer. These variants may also be associated with an increased risk for prostate cancer and certain other cancers. This test includes three genetic variants in the BRCA1 and BRCA2 genes that are most common in people of Ashkenazi Jewish descent.
Every human carries two copies of the genetic code, one inherited from the mother and one from the father, some 6 billion letters in all. Apart from identical twins, no two individuals have the same genetic code. With the exception of the egg and sperm cells, all the cells of our bodies have 23 pairs of chromosomes, 46 in all. One chromosome of the pair is inherited from the father and one from the mother. However, in males the 23rd pair consists of a so-called Y-chromosome and an X-chromosome, whereas females have two X-chromosomes. The Y chromosome contains a gene which triggers embryonic development as a male and carries information about the male’s paternal lineage.
In McCartney’s view, enough testing is already done in this country (sometimes too much) and there are issues of regulation and “informed consent”. “People are given very dramatic reasons to have these tests – it could help save your life, it could help improve the quality of your life – but where is the actual controlled evidence that these tests have ever done that? There’s no evidence that says doing these tests makes people become healthier.”
If you’ve already taken a test with another company, MyHeritage lets you upload your raw data to its database for free. This feature is particularly useful if you’re looking for lost relatives, as you can pay slightly more for one test with Ancestry or 23andMe, which have larger databases, but still access MyHeritage’s database as well, which has 1.75 million users as of October 2018.
Y-DNA Tests: Y-DNA testing examines the Y chromosome passed only from father to son and can therefore be used to gain a better understanding of your paternal line. This can be a very interesting study for those focused on surname research, especially since the Y chromosome can give information about deep and recent roots. Because only men carry this chromosome women will need to test their father, brother or other male relation to use this test for genealogy purposes. Again, FTDNA is the leader in this type of testing and has a wealth of information, groups and forums to help.