The DNA tests we reviewed either require a saliva or cheek cell sample. Saliva-collecting kits include a tube that’s marked with a fill line and sample number. The tube often has a liquid-filled cap with a stabilizer that acts as a preservative to protect your DNA from degradation during transport. Cheek swab sample kits include one or two swabs for scraping the insides of your cheeks for 30 seconds to a minute to collect cheek cells and some sort of container to place the used swabs into after collection. This prevents contamination. Our testers found upsides to both types of kits but generally preferred saliva collection kits, even though they took longer.
An ancestry DNA test uses a saliva sample to determine which areas of the world your DNA can be traced back to. DNA kits have become very popular during the last few years. This has led to many people having numerous questions. You may be wondering if your genetic information will be used for research or sold and how this impacts your privacy. You may also be concerned regarding the accuracy of this test or have numerous additional questions. The first thing you must realize is the question of your DNA is complex and there may not be a simple answer. The majority of people in the world have DNA from numerous different regions. You may perceive this combination as unique or you may see it is odd. Either way, you need to be open and prepared for a surprise.
Thank you for such detailed information. I’m considering buying a DNA ancestry kit for my wife for Christmas (and buying one for myself as well). After reading your article (and many of the wonderful comments), I’m leaning towards the one from Ancestry.com. However, would I still get complete results without a subscription? I looked on their website and it doesn’t say.
While men can trace both their maternal haplogroup (from mitochondrial DNA) and their paternal haplogroup (through the Y chromosome passed down from their father), women can only trace their maternal haplogroup (through the mitochondrial DNA passed down from their mother). This is because the paternal haplogroup is traced through the Y chromosome, which women do not inherit.
Although the project states that most participants won’t receive any useful information, patients will be told if something is found in their genome that is relevant to the treatment, explanation or diagnosis of their condition. They can also choose to learn if they have a genetic risk factor for another disease, such as the BRCA1 gene mutation that can cause breast cancer. Genomics England will only look for risk factors that are linked to a disease that can be treated or prevented. Untreatable conditions, such as Alzheimer’s, are not looked for.

To prepare to take a cheek swab sample, you also have to refrain from eating for about an hour before. Swab kits generally contain more components, including one or two swabs and containers to protect the used swabs from contamination. We found it easiest to organize all the pieces first, to prevent any fumbling with a sample collection swab in hand. Some cheek cell kits put a stabilizing liquid in the sample containers, which required extra caution to prevent spilling.
Which is all very well, but do these kits work and deliver the service they promise and what about the wider ethics and implications of home genetic testing? Is it always wise for generally under-informed, under-prepared consumers to meddle in the highly complex, nuanced arena of genetics, risking confusion, complacency or even outright panic and anxiety when confronted with ostensible “bad news” (which may not even be true)?
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