When my results appear, they show nothing bad. If anything, it’s anticlimactic: cholesterol, vitamins, liver proteins and the like are all in the normal range, with only ferritin (iron stores) slightly high, with a recommendation to go easy on any iron supplements. My problem with the baseline test is that, unlike Thriva’s other products, clients are supposed to have one every three months to keep track, but would I really want (or indeed need) to do such a test so regularly?
Even the cousin matches seem to be based on the surnames listed in your tree with no attempt at comparing the people between trees to see if there is actually anyone in common! I have managed to find a few actual matches in the cousin match list, no thanks to their matching service, but more to the fact that I have been researching my tree for many years and am fortunate to know someone who is very competent at DNA and family tree research to help me weed out the rubbish from the genuine matches.
Every company providing DNA testing has their own database of DNA samples. These are called AIM’s or ancestry informative markers. These markers were derived from the current populations of America, Asia, Europe and Africa. Every database is looking for a pair of genes located on a specific chromosome in a specific position. The way the DNA is evaluated is through the SNP’s or the single nucleotide polymorphisms. The SNP’s are chosen according to the frequency in a specific geographical population. Your SNP’s are compared to the most common SNP’s for the various populations in the company’s reference database. The results are not conclusive because they are based on common genetic variations. The probability for your DNA being from a certain country is based on a comparison between your DNA and the database. If you used a different company, they would have a different database. This means your results would most likely differ. According to studies, the lowest concordance is with individuals of South Asian, East Asian and Hispanic descent.
When asked about how database size affects ancestry results, David Nicholson, co-founder of Living DNA, told us, “The tests absolutely rely on the reference database. If you have Polish ancestry but there are no people in the database who are Polish, then what the test will do is show what the next closest group is next to Polish, like German or Eastern European ancestry.” Each ancestry DNA service has its own sample database and reference panel made of the DNA samples collected from their users and information collected from sources like the 1000 Genomes Project. The database consists of all this information collectively. A reference panel is made of certain curated samples with known family history and roots in a specific place. The services use insights gleaned from the reference panel to give you geographical ancestry results. In theory, a larger database leads to more information available to create a good reference panel, which then leads to better results for customers.
This is a large amount of data not being used by services testing DNA. There are millions of SNP’s contained in your DNA. This type of testing only looks at specific variations. This requires between 100 and 300 AIM’s. This is a small fraction of the SNP’s differentiating DNA. This means if your test stated you are fifty percent European, it means only half of your SNP’s appear to be European. Another issue is certain markers used for ancestry information for any given test are only derived from either your Y chromosomes or your paternal line or your mitochondrial DNA or maternal line. When these markers are used, your test will be less accurate. Another flaw is the DNA testing services are obtaining DNA from the current populations in specific regions. This makes unsubstantiated conclusions that the people living in these areas hundreds of thousands of years in the past have had the same DNA for all these years.
There are mixed reactions to the use of ancestry DNA databases in criminal cases. On one hand, the rise of readily-available DNA information for millions of people has led to the arrests of several suspects related to long-cold cases, including the arrest of the Golden State Killer. On the other hand, law enforcement accessing private databases of genetic information from consumers raises several questions regarding privacy and ethical issues.
Although the project states that most participants won’t receive any useful information, patients will be told if something is found in their genome that is relevant to the treatment, explanation or diagnosis of their condition. They can also choose to learn if they have a genetic risk factor for another disease, such as the BRCA1 gene mutation that can cause breast cancer. Genomics England will only look for risk factors that are linked to a disease that can be treated or prevented. Untreatable conditions, such as Alzheimer’s, are not looked for.
Hello…so I am interested in purchasing a few test for myself, my sister and my brother for Christmas. Primary interest is just seeing what our true roots are. Growing up we have been told we are Native American (Nipmuc tribe) and african american with some roots in Jamaica but I would love to see how accurate that all is. Not really looking to get “connected” to any long lost relatives but it would be great to know where in the world we “originate” from when looking into our ancestry. Which test would be the best for these results? Thank you… Read more »
Although FamilyTreeDNA is the only DNA testing company openly working with law enforcement, other DNA companies don’t necessarily keep your DNA information private. Many direct-to-consumer DNA testing companies sell your data to third parties. For example, 23andMe shares customer data with pharmaceutical giant GlaxoSmithKline, which uses the information to develop medical treatments. In this case, you can opt out of having your DNA information used for research, and the data is shared only in aggregate.
McCartney says that anxious people often contact her, saying they wished they hadn’t done the tests. “These companies often say that it’s worth it for the helpful advice. But I can give you really good advice right now without seeing a single test result: be active, have lots of social networks, do work you enjoy, try not to smoke or drink too much, don’t be overweight or underweight, eat lots of fresh fruit and vegetables. Nobody needs to get tests done to get that kind of basic lifestyle advice.”