DNA test companies that use genotyping technology, including 23andMe and Ancestry, allow you to download your raw DNA file. A raw DNA file is usually a text file that contains all the information about your genetic code gleaned from the company’s examination of your DNA. This is comprised of several hundred thousand markers known as SNPs (Single Nucleotide Polymorphisms). Most raw files are organized into five columns: the SNP coded into an rsID number, the chromosome the SNP is located on, the location of the SNP on the chromosome and the two alleles for each SNP.
The 100,000 Genomes Project is an NHS initiative, run by Genomics England, and is the largest national genome sequencing project in the world. On entering, patients have their entire genome, of more than 3bn base pairs, sequenced. This is different from commercially available genetic testing kits, such as those from 23andMe, which only look at very small stretches of DNA in a process called genotyping. The hope of the NHS is that having so much genetic information, from so many different people, will allow “groundbreaking discoveries about how diseases work, who could be susceptible to them, how we can treat them, and what treatments might work”.
Looking at your raw DNA file might not give you any useful information unless you’re looking for a specific marker. You can also upload the file into a third-party DNA databases for information or results beyond what’s available from your testing company. This process is not without risks, as your DNA testing company only ensures the security of your personal information in its own environment. Once you download the file, you’re responsible for the file’s security. However, uploading your raw DNA to a third party database isn’t inherently unsafe — just be cautious.
I am not sure how Ancestry get their results. Mine is 49% British and 49% German. This means one of my parents must have been British and the other German. I moved to the UK 15 years ago. But both my parents where German as where my 4 grandparents and my 8 great-grandparents. It seems to me they have rolled the dice and assumed that if you send a sample from the UK you must have British ancestry. No science behind it at all. I could have gone to the oracle at the fun fair.
A friend of mine knew I had been working on my family history and bought me an AncestryDNA kit for my birthday. My results were surprising to say the least. I discovered I’m 35% Native American, 5% African and 29% from the Iberian Peninsula. This has drastically broadened the way I think about my identity and heritage. I feel connected to those parts of the world now and I’m excited to see how far back our records can go.
If the company responsible for running your test is sold, whatever you signed loses significance due to the privacy policies of the company. Despite most of these privacy policies stating they will notify you of any changes, you would have to keep in constant contact with the company to ensure you were actually aware of these changes. The people willing to do this would be far and few between. Unfortunately, even if your name is not located within the database, this does not mean other databases cannot be used to determine your identity. In one specific case, a woman had a DNA test run. She found out she had a half-sibling. Although she was very excited about this news, this type of information would devastate numerous individuals.
Hello, I have done fair amount of research into my genealogy. I have found extensive info on many of the family trees yet have hit a wall with my paternal line. I have only been able to trace back to my grandfather, his father, my ggrandfather, is a mystery. I have only found a marriage certificate and some minutes from a church meeting. Would the y-dna test be the most revealing? (My brother did an Ancestry test that was interesting but not that revealing.)
In this case, I would recommend two options: 1. Ancestry.com – If you choose to take their DNA test, you can also take advantage of their family tree feature. Your DNA test results would be compared to other samples in the database. Combining this, with a manual lookup you can do, you might trace relatives on your father’s lineage. 2.LivingDNA – LivingDNA provides a separate unique analysis of the paternal lineage. This analysis will give you an in-depth picture of your father’s heritage. The only drawback is that LivingDNA database is relatively small (compared to ancestery.com and other big competitors). You can bridge that gap using GEDMatch service, by uploading your raw DNA data (acquired by LivingDNA). You can read more about GEDMatch here. Good luck and I hope you would find what you are looking for!
There are many places you can upload your raw DNA, and several of them are free. Popular third-party DNA analysis tools include GEDmatch and Promethese. GEDmatch is a free, open database and genealogy site that gives additional DNA relative matching and trait results. This tool has information from users of multiple different testing companies. Promethease compares your raw DNA information against scientific reports that link certain markers to health conditions, though you should take these results with a grain of salt as genetic links do not equal a diagnosis.
Self-collection DNA test kits are a convenient and more affordable option. However, the support and advice you receive when making an appointment to have your DNA sample taken is invaluable and we will always recommend this option to you. To locate your nearest DNA testing clinic, pharmacy or mobile sample collection service please use the location search tool.
I was born in NYC, the youngest of five kids. My parents and three older siblings were born in Bogota, Colombia. My name implies Hispanico/Latino roots but when I’m with my Polynesian friends people always think I’m Hawaiian or a mix of Polynesian and something else. I recently attended a Nepali church service and people asked me what part of Nepal I was from.
All this comes into sharp focus with the comprehensive kits such as the one provided by 23andMe: the one I drool into a tube for (incidentally, 23andMe doesn’t test for Huntington’s disease). Most people, like myself, have a low understanding of genetic variants, what phrases such as “higher risk” or “probability” actually mean or how to interpret our results correctly. Is it right that ordinary members of the public must navigate potentially frightening and/or misleading results alone?
For about $20 less than other DNA ancestry services, MyHeritage DNA gives you an ethnicity estimate and access to DNA matches. It’s true value, however, lies in its free raw DNA uploads. If you’ve already taken a test with another company, MyHeritage lets you upload your raw data to its database for free. This feature is particularly useful if you’re looking for lost relatives, as you can pay slightly more for one test with Ancestry or 23andMe, which have larger databases, but still access MyHeritage’s database as well, which has 1.75 million users as of October 2018. With a 16-day turnaround, MyHeritage DNA was one of the first companies to send back our test results, but I found the contents of my ancestry report to be a bit off, especially when compared to my geographic ancestry reports from other companies. I was born in Korea and therefore expected at least a little of my Korean heritage to make it onto my ancestry map, as it did with other services, but MyHeritage didn’t report any Korean heritage. Instead, MyHeritage DNA reported I that I’m of Japanese, Chinese and Vietnamese, and Mongolian descent. As I was looking for a reason to explain the discrepancy between tests, I discovered that there are large swaths of the map not covered by any of the service’s ancestral regions. The Korean peninsula is one of those areas, as are southern regions in South America, Africa and almost all of Australia and Russia. The oversight seems odd because MyHeritage could have easily included these missed areas inside a larger, generalized region instead of completely omitting them.
While men can trace both their maternal haplogroup (from mitochondrial DNA) and their paternal haplogroup (through the Y chromosome passed down from their father), women can only trace their maternal haplogroup (through the mitochondrial DNA passed down from their mother). This is because the paternal haplogroup is traced through the Y chromosome, which women do not inherit.
More controversially, some of these kits profess to tell you your biological (as opposed to actual age) by measuring the length of your telomeres (in basic terms, the caps at the end of each strand of DNA that protect chromosomes, like plastic tips at the end of shoelaces). Other tests, such as 23andMe, predict higher risks of developing serious conditions, such as multiple sclerosis, Alzheimer’s and Parkinson’s, including the test for BRCA1/BRCA2 (breast and ovarian cancer) that Angelina Jolie famously underwent, going on to have a preventative double mastectomy and surgery to remove her ovaries.